Renée Zellweger will make her directorial debut with 4 1/2 Minutes, Variety reports, which she’ll also co-star in opposite Johnny Knoxville. Go ahead, imagine that sentence sounding true in 2000. The movie, based on a true story, follows a struggling stand-up comedian (Knoxville) whose crappy life gets turned around when he starts taking care of the genius son of a single mother (Zellweger). Well, you know what they say, stand-up comedians love babysitting.