Rob Lowe.
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Most Comedy Central roasts include a mix of professional comedians and random famous people, but perhaps no roast will have as many of the latter as the upcoming roast of Rob Lowe. According to the full lineup, there’s almost no slob pros at the Rob Lowe roast; besides reliable comics like David Spade and Jeffrey Ross, the Grinder star will be insulted by bold-faced names like Ann Coulter, Ralph Macchio, Peyton Manning, and Jewel. What in the world is Jewel going to say? Well, according to Lowe’s 2014 memoir, during her guest stint on The Lyons Den, the singer-songwriter made a big show of wiping her mouth after filming a kissing scene with him. So, probably that.